AECA
Pronunciation: AY-eh-kah
Also written as: AECA — Anti-Endothelial Cell Antibodies
Anti-endothelial cell antibodies that target vascular endothelium and can cause blood-brain barrier dysfunction.
Full Definition
Anti-endothelial cell antibodies (AECA) are autoantibodies directed against antigens on the surface of endothelial cells lining blood vessels. In the context of neuroimmunology, AECA can target cerebral endothelium, leading to blood-brain barrier compromise and increased vascular permeability. These antibodies are implicated in various neuroinflammatory conditions and vasculitic syndromes affecting the central nervous system. AECA detection may help identify patients with autoimmune-mediated vascular inflammation.
Usage
Usage note: Use all capitals when abbreviated; spell out on first use in formal documents.
In Context
- "Elevated AECA levels were detected in patients with suspected cerebral vasculitis." — Laboratory report
- "The presence of AECA correlated with blood-brain barrier disruption on neuroimaging." — Clinical research study