Banki index
Pronunciation: BANK-ee
A CSF biomarker ratio used to assess blood-brain barrier integrity and intrathecal inflammation in neuroinflammatory diseases.
Full Definition
The Banki index is a cerebrospinal fluid biomarker calculated as the ratio of CSF to serum concentrations of specific proteins or immunoglobulins, adjusted for albumin ratios to account for blood-brain barrier function. This index helps distinguish between systemic and intrathecal (within the CNS) production of inflammatory mediators. Values above established thresholds suggest local CNS synthesis rather than passive diffusion from blood. The Banki index is particularly useful in diagnosing and monitoring neuroinflammatory conditions such as multiple sclerosis, where intrathecal immunoglobulin synthesis is a key diagnostic feature.
Usage
Usage note: Capitalize 'Banki' as it is an eponymous term.
In Context
- "The elevated Banki index confirmed intrathecal immunoglobulin synthesis in this patient with suspected multiple sclerosis." — Laboratory report
- "Serial Banki index measurements were used to monitor treatment response in the neuroinflammatory disorder." — Clinical monitoring report