lymphocyte subset analysis
Flow cytometric characterization of T-cell and B-cell populations in blood or cerebrospinal fluid samples.
Full Definition
Lymphocyte subset analysis involves the detailed characterization of different lymphocyte populations using flow cytometry with multiple fluorescent antibodies targeting specific cell surface markers. In neuroimmunology, this analysis typically includes quantification of CD4+ and CD8+ T cells, B cells, natural killer cells, and various T-cell subsets including regulatory T cells (Tregs), Th1, Th2, and Th17 populations. CSF lymphocyte subset analysis can reveal patterns of immune activation specific to different neuroinflammatory conditions and help monitor the effects of immunomodulatory treatments. The technique provides insights into the cellular immune responses occurring within the central nervous system compartment.
Usage
Usage note: Specify whether analysis is of blood, CSF, or tissue samples; include methodology details.
In Context
- "Lymphocyte subset analysis revealed a predominance of CD8+ T cells in the patient's CSF." — Immunology laboratory report
- "Treatment with natalizumab significantly altered peripheral lymphocyte subset distributions." — Treatment monitoring study