Marburg variant
Pronunciation: MAR-burg
Acute, rapidly progressive form of multiple sclerosis with severe inflammation and poor prognosis.
Full Definition
Marburg variant multiple sclerosis, also known as acute multiple sclerosis or Marburg-type MS, is a rare and aggressive form of multiple sclerosis characterized by rapid progression, severe clinical disability, and often fatal outcome within months to years of onset. This variant was first described by Otto Marburg in 1906 and is distinguished by its fulminant inflammatory course, large confluent demyelinating lesions, and poor response to standard treatments. The condition requires aggressive immunosuppressive therapy and represents one of the most severe forms of inflammatory demyelinating disease.
Usage
Usage note: Named after Otto Marburg; capitalize when used as an eponym.
In Context
- "The patient's rapid neurological deterioration and MRI findings were consistent with Marburg variant multiple sclerosis." — Case presentation
- "Aggressive immunosuppression was initiated given the suspected Marburg variant diagnosis." — Treatment plan