MOG antibodies
Also written as: MOG — myelin oligodendrocyte glycoprotein
Antibodies targeting myelin oligodendrocyte glycoprotein, associated with a distinct demyelinating syndrome.
Full Definition
Myelin oligodendrocyte glycoprotein (MOG) antibodies are autoantibodies that target MOG, a protein found on the outer surface of myelin sheaths. MOG antibody-associated disease (MOGAD) is now recognized as a distinct clinical entity separate from multiple sclerosis and neuromyelitis optica. Patients typically present with optic neuritis, transverse myelitis, or acute disseminated encephalomyelitis-like symptoms. Unlike AQP4-NMOSD, MOG antibody disease often has a more favorable prognosis and may be monophasic, though relapses can occur. Testing requires cell-based assays for accuracy.
Usage
Usage note: Distinguish from MOG protein itself; specify testing methodology when discussing results.
In Context
- "The patient tested positive for MOG antibodies using cell-based assays." — Laboratory report
- "MOG antibody-associated disease often presents with bilateral optic neuritis." — Case report