perivascular cuffing
Histopathological finding characterized by inflammatory cell infiltration around blood vessels in the CNS.
Full Definition
Perivascular cuffing is a characteristic histopathological feature observed in various neuroinflammatory conditions, where inflammatory cells accumulate around blood vessels within the central nervous system. This finding typically involves lymphocytes, macrophages, and other immune cells forming sleeve-like arrangements around cerebral vessels. Perivascular cuffing is commonly seen in multiple sclerosis, viral encephalitis, and other inflammatory CNS disorders, and represents a key indicator of blood-brain barrier disruption and immune cell infiltration.
Usage
Usage note: Always hyphenate as perivascular-cuffing when used as a compound modifier.
In Context
- "Histological examination revealed extensive perivascular cuffing consistent with active neuroinflammation." — Pathology report
- "The presence of perivascular cuffing supports the diagnosis of inflammatory demyelinating disease." — Diagnostic assessment