radiologically isolated syndrome
Incidental MRI findings suggestive of multiple sclerosis in asymptomatic individuals.
Full Definition
Radiologically isolated syndrome (RIS) refers to the incidental discovery of brain MRI abnormalities consistent with multiple sclerosis in individuals who have never experienced clinical symptoms suggestive of neurological disease. These findings typically include multiple T2-hyperintense lesions in characteristic locations for MS. RIS represents a pre-clinical stage that may progress to clinically apparent MS, though not all individuals with RIS will develop symptoms. The management of RIS remains controversial, with ongoing research investigating the role of early intervention.
Usage
Usage note: Distinguish from 'subclinical MS' which implies definite disease presence.
In Context
- "The patient's brain MRI performed for headache evaluation revealed findings consistent with radiologically isolated syndrome." — Radiology report
- "Long-term monitoring was recommended for this case of radiologically isolated syndrome." — Neurology consultation