Becker muscular dystrophy

Full Definition

Becker muscular dystrophy (BMD) is an X-linked recessive disorder caused by mutations in the dystrophin gene that result in reduced or abnormal dystrophin protein production. Unlike Duchenne muscular dystrophy, BMD presents with a milder phenotype and later onset, typically in adolescence or adulthood. Patients experience progressive proximal muscle weakness, particularly affecting the legs and pelvis, with preservation of ambulation well into adulthood. Cardiac involvement is common and may be the presenting feature. The condition is diagnosed through genetic testing, dystrophin immunostaining, and clinical assessment.

Usage

Usage note: Named after Peter Emil Becker; capitalize both words when writing the full name.

In Context

• "The patient's late-onset weakness and positive dystrophin staining suggested Becker muscular dystrophy rather than Duchenne." — Clinical assessment
• "BMD typically allows patients to maintain ambulation into their 40s or 50s." — Patient counseling notes