anticholinesterase test
A diagnostic procedure using edrophonium or neostigmine to temporarily improve muscle weakness in myasthenia gravis.
Full Definition
An anticholinesterase test involves the administration of short-acting cholinesterase inhibitors such as edrophonium (Tensilon) or longer-acting agents like neostigmine to evaluate suspected myasthenia gravis. These medications prevent the breakdown of acetylcholine at the neuromuscular junction, temporarily increasing available neurotransmitter and improving muscle strength if myasthenia gravis is present. The test requires careful monitoring due to potential cardiac side effects, and atropine should be readily available. While historically important, this test has largely been superseded by antibody testing and electrodiagnostic studies.
Usage
Usage note: Use hyphens in 'anticholinesterase' as a compound adjective.
In Context
- "The anticholinesterase test showed marked improvement in ptosis, supporting the diagnosis of myasthenia gravis." — Clinical documentation
- "Given the availability of more specific tests, the anticholinesterase test is now rarely performed." — Medical review article