IVIG
Pronunciation: EYE-vig
Also written as: IVIG — Intravenous Immunoglobulin
Intravenous Immunoglobulin. A blood product therapy used to treat various autoimmune neuromuscular conditions including myasthenia gravis and inflammatory neuropathies.
Full Definition
Intravenous Immunoglobulin (IVIG) is a therapeutic blood product containing concentrated antibodies from thousands of healthy donors, administered intravenously to treat autoimmune and inflammatory conditions. In neuromuscular medicine, IVIG is commonly used for myasthenia gravis, CIDP, multifocal motor neuropathy, and dermatomyositis. The therapy works through multiple mechanisms including modulation of autoantibody production, complement inhibition, and immune system regulation. Standard dosing is typically 2 g/kg administered over 2-5 days, though maintenance regimens vary by condition. Side effects can include headache, flu-like symptoms, and rarely, thrombotic events or renal dysfunction.
Usage
Usage note: Specify dosing regimen and indication. Monitor for infusion reactions and contraindications.
In Context
- "The patient showed marked improvement in muscle strength following a 5-day course of IVIG at 0.4 g/kg/day." — Treatment response note
- "Monthly IVIG infusions were initiated for maintenance therapy of refractory myasthenia gravis." — Treatment plan