Myasthenia Gravis
Pronunciation: my-as-THEE-nee-ah GRAV-is
An autoimmune neuromuscular disorder characterized by weakness and fatigue of skeletal muscles. The condition involves antibodies blocking acetylcholine receptors at the neuromuscular junction.
Full Definition
Myasthenia gravis is a chronic autoimmune neuromuscular disorder that causes weakness and rapid fatigue of voluntary muscles. The condition occurs when antibodies block or destroy acetylcholine receptors at the neuromuscular junction, preventing proper muscle contraction. Symptoms typically worsen with activity and improve with rest. The disease can affect muscles controlling eye movement, facial expression, chewing, swallowing, and limb movement. Treatment often involves immunosuppressive medications and cholinesterase inhibitors.
Usage
Usage note: Often abbreviated as MG in clinical documentation. Always use lowercase 'gravis' in formal medical writing.
In Context
- "The patient's myasthenia gravis showed marked improvement following plasmapheresis." — Clinical case report
- "Differential diagnosis included myasthenia gravis versus congenital myasthenic syndromes." — Medical consultation note