myasthenic crisis
Life-threatening exacerbation of myasthenia gravis requiring mechanical ventilation due to respiratory muscle weakness.
Full Definition
Myasthenic crisis represents a medical emergency characterized by severe exacerbation of myasthenia gravis symptoms, particularly affecting respiratory and bulbar muscles, often necessitating mechanical ventilation. This condition can be triggered by infections, medications, surgery, pregnancy, or inadequate immunosuppressive treatment. Patients present with severe generalized weakness, dysphagia, dysarthria, and respiratory failure. Management requires immediate airway protection, mechanical ventilation if necessary, and intensive immunosuppressive therapy such as plasmapheresis or intravenous immunoglobulin. Careful medication management is crucial, as anticholinesterase medications may need to be temporarily discontinued.
Usage
Usage note: Hyphenate when used as a compound adjective.
In Context
- "The patient was admitted to the ICU for myasthenic crisis with impending respiratory failure." — Hospital admission note
- "Plasmapheresis was initiated immediately for treatment of the myasthenic crisis." — Critical care documentation