eosinophilic inclusion
Pink-staining intracellular protein aggregates visible in routine histological sections, often indicating neurodegeneration.
Full Definition
Eosinophilic inclusions are abnormal protein accumulations within neurons or glial cells that appear pink or red on standard hematoxylin and eosin staining. These structures can represent various pathological processes including protein misfolding, aggregation, or cellular stress responses. Examples include Lewy bodies, Pick bodies, Mallory bodies, and viral inclusions. The morphology, location, and immunohistochemical profile of these inclusions often provide crucial diagnostic information for specific neurodegenerative diseases, infections, or metabolic disorders.
Usage
Usage note: Specify the type and location of inclusion when possible.
In Context
- "Numerous eosinophilic inclusions were present in the substantia nigra neurons." — Parkinson disease autopsy report
- "The eosinophilic inclusions showed positive immunoreactivity for alpha-synuclein." — Immunohistochemistry results