ependymoma
Pronunciation: eh-PEN-di-moh-mah
A brain tumor arising from ependymal cells that line the ventricles and central canal of the spinal cord.
Full Definition
Ependymoma is a type of glioma that originates from ependymal cells, which line the ventricular system and central canal of the spinal cord. These tumors can occur throughout the central nervous system but are most common in the posterior fossa in children and the spinal cord in adults. Ependymomas are characterized by distinctive histological features including perivascular rosettes and ependymal rosettes. The WHO classification recognizes several subtypes with different molecular profiles and clinical behaviors. Modern diagnosis increasingly incorporates molecular markers alongside traditional histological features to improve prognostic accuracy and treatment planning.
Usage
Usage note: Specify anatomical location and molecular subtype when known; distinguish from other periventricular tumors.
In Context
- "The posterior fossa mass was diagnosed as WHO grade II ependymoma with classic perivascular rosettes." — Pediatric brain tumor report
- "Molecular profiling confirmed RELA fusion-positive supratentorial ependymoma." — Molecular neuropathology report