gemistocytic astrocyte
Pronunciation: jem-is-toe-SIT-ik
Enlarged astrocyte with abundant eosinophilic cytoplasm, indicating reactive change or low-grade glioma.
Full Definition
Gemistocytic astrocytes are enlarged astrocytic cells characterized by abundant, eosinophilic cytoplasm and eccentric nuclei, representing either reactive changes to brain injury or a component of certain low-grade gliomas. The term 'gemistocytic' derives from the Greek word meaning 'stuffed' or 'filled,' referring to the cell's swollen appearance. While reactive gemistocytes respond to various brain insults, neoplastic gemistocytes are a defining feature of gemistocytic astrocytomas, a subtype of diffuse astrocytoma with a tendency for malignant transformation.
Usage
Usage note: Can be shortened to 'gemistocyte' when cell type is clear from context.
In Context
- "Numerous gemistocytic astrocytes were present throughout the tumor specimen." — Low-grade glioma diagnosis
- "The reactive tissue contained scattered gemistocytic astrocytes around the infarct border." — Stroke pathology