ganglioglioma
Pronunciation: gang-glee-oh-glee-OH-mah
A mixed glial-neuronal tumor composed of neoplastic neurons and glial cells, often presenting with seizures.
Full Definition
Ganglioglioma is a mixed glial-neuronal tumor composed of both neoplastic neurons (ganglion cells) and glial cells, typically astrocytes. These WHO grade I tumors are most common in children and young adults, with a strong predilection for the temporal lobe where they frequently present with chronic epilepsy. The neuronal component consists of large, dysplastic ganglion cells with enlarged nuclei and prominent nucleoli, while the glial component resembles a low-grade astrocytoma. Gangliogliomas may show calcification, cystic change, and perivascular lymphocytic infiltration. The neuronal component is positive for neuronal markers (NeuN, synaptophysin), while the glial component shows GFAP positivity. Complete surgical resection is typically curative.
Usage
Usage note: Emphasize mixed neuronal-glial nature and seizure presentation.
In Context
- "The temporal lobe epilepsy surgery revealed ganglioglioma with prominent dysplastic neurons." — Epilepsy surgery pathology report
- "Ganglioglioma was confirmed by the presence of both NeuN-positive neurons and GFAP-positive glia." — Immunohistochemical analysis report