glioblastoma multiforme
Pronunciation: glee-oh-blas-TOH-mah mul-ti-FOR-may
Also written as: GBM — Glioblastoma Multiforme
The most aggressive primary brain tumor (WHO grade IV), characterized by rapid growth and poor prognosis.
Full Definition
Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor classified as WHO grade IV astrocytoma. It is characterized by rapid growth, extensive invasion into surrounding brain tissue, and resistance to treatment. The term 'multiforme' refers to the varied appearance of tumor cells and tissue patterns seen on microscopic examination. GBM typically presents in older adults and carries a very poor prognosis with median survival of approximately 12-15 months. Editors should note that the current WHO classification prefers the simplified term 'glioblastoma' over the full 'glioblastoma multiforme'.
Usage
Usage note: Modern preference is for 'glioblastoma' rather than full term; always specify WHO grade IV.
In Context
- "The patient was diagnosed with glioblastoma multiforme based on histopathological and molecular features." — Case report
- "Survival analysis included 127 patients with newly diagnosed GBM." — Clinical research study