hemosiderin-laden macrophage

Full Definition

Hemosiderin-laden macrophages are phagocytic cells containing iron deposits derived from the breakdown of hemoglobin following hemorrhage. In brain tissue, these cells serve as markers of previous bleeding episodes and can persist for months to years after the initial hemorrhagic event. They appear as golden-brown pigmented cells on routine staining and can be highlighted with iron stains such as Perl's Prussian blue. Their presence helps pathologists date hemorrhagic events and identify areas of chronic microbleeding.

Usage

Usage note: Use hyphenated form; can be shortened to 'siderophages' in appropriate context.

In Context

• "Hemosiderin-laden macrophages indicated remote hemorrhage at the lesion margins." — Brain biopsy report
• "The accumulation of hemosiderin-laden macrophages suggests chronic microhemorrhages." — Cerebral amyloid angiopathy diagnosis