neuronal loss
Reduction in the number of neurons in brain tissue, a key feature of neurodegenerative diseases.
Full Definition
Neuronal loss refers to the death and disappearance of neurons from brain tissue, resulting in reduced cell density in affected regions. This process is a hallmark of neurodegenerative diseases and can occur through various mechanisms including apoptosis, necrosis, or autophagy. Neuronal loss is typically accompanied by reactive gliosis and can be quantified through stereological methods or assessed qualitatively. The pattern and severity of neuronal loss often correlate with clinical symptoms and disease progression in conditions such as Alzheimer disease, Parkinson disease, and motor neuron disease.
Usage
Usage note: Specify the anatomical location and cell types affected when possible.
In Context
- "Severe neuronal loss was evident in layer II of the entorhinal cortex." — Alzheimer disease autopsy report
- "The neuronal loss appeared selective, primarily affecting large pyramidal neurons." — Frontotemporal dementia study