perivascular space
Fluid-filled spaces surrounding blood vessels in the brain, also known as Virchow-Robin spaces.
Full Definition
Perivascular spaces, historically called Virchow-Robin spaces, are cerebrospinal fluid-filled cavities that surround penetrating arteries and arterioles as they enter brain parenchyma. These spaces are lined by pia mater and represent extensions of the subarachnoid space into brain tissue. While normally microscopic, enlarged perivascular spaces can become visible on imaging and may indicate various pathological processes including aging, hypertension, or inflammatory conditions. In neuropathology, assessment of perivascular space morphology helps evaluate cerebrovascular disease and neuroinflammation.
Usage
Usage note: Prefer 'perivascular space' over the eponymous 'Virchow-Robin space' in modern usage.
In Context
- "Enlarged perivascular spaces were noted in the basal ganglia region on microscopic examination." — Neuropathology report
- "The perivascular space showed inflammatory cell infiltration consistent with vasculitis." — Diagnostic finding