Advanced
Technical
In the Industry Vocabulary Test
pseudopalisading
Pronunciation: SOO-doh-pal-ih-say-ding
Arrangement of elongated cell nuclei around areas of necrosis, characteristic of glioblastoma.
Full Definition
Pseudopalisading refers to the distinctive pattern where tumor cell nuclei arrange themselves in a fence-like formation around zones of necrosis, particularly in high-grade gliomas. Unlike true palisading, this arrangement is irregular and incomplete. The phenomenon results from tumor cells migrating away from hypoxic areas while maintaining some organization. This histological feature is one of the defining characteristics of glioblastoma and indicates aggressive tumor behavior with rapid growth and inadequate vascularization.
Usage
Usage note: Distinguish from true palisading seen in other tumor types.
In Context
- "Extensive pseudopalisading around necrotic foci confirmed the diagnosis of glioblastoma." — Tumor pathology report
- "The pseudopalisading pattern was less pronounced in this WHO grade III astrocytoma." — Histological comparison
Also known as
pseudopalisade formation
Contrasted with
true palisading
Don't confuse with
true palisading
perivascular arrangement