Rosenthal fiber

Full Definition

Rosenthal fibers are distinctive, elongated, eosinophilic inclusions found within astrocytic cytoplasm, composed of intermediate filaments and stress proteins including GFAP and αB-crystallin. Named after Werner Rosenthal, these structures are pathognomonic of certain conditions, particularly pilocytic astrocytomas and Alexander disease. They represent a form of astrocytic stress response and protein aggregation. Their identification is crucial for tumor classification and genetic disease diagnosis in neuropathology.

Usage

Usage note: Capitalize 'Rosenthal' as it derives from Werner Rosenthal's name.

In Context

• "Abundant Rosenthal fibers were present throughout the pilocytic astrocytoma." — Brain tumor diagnosis
• "The identification of Rosenthal fibers supports the diagnosis of Alexander disease." — Genetic disease workup