subcortical arteriosclerotic encephalopathy
Pronunciation: BINZ-wang-er
Progressive white matter disease caused by chronic small vessel disease, also known as Binswanger disease.
Full Definition
Subcortical arteriosclerotic encephalopathy, also known as Binswanger disease, is a form of vascular dementia characterized by chronic ischemic damage to subcortical white matter due to small vessel disease. The condition results from arteriosclerosis of deep penetrating arteries, leading to chronic hypoperfusion and progressive white matter degeneration. Pathologically, it shows pallor and rarefaction of subcortical white matter, enlarged perivascular spaces, and small lacunar infarcts. The cortical gray matter is typically spared. Clinically, patients present with progressive cognitive decline, gait disturbances, and urinary incontinence. The condition is strongly associated with hypertension and other vascular risk factors.
Usage
Usage note: Can be abbreviated as SAE; Binswanger is an acceptable alternative term.
In Context
- "The autopsy findings were consistent with subcortical arteriosclerotic encephalopathy." — Vascular dementia case
- "Binswanger disease was diagnosed based on the pattern of white matter changes." — Neuropathological consultation