subependymal giant cell astrocytoma
Also written as: SEGA — subependymal giant cell astrocytoma
A WHO grade I tumor arising from subependymal nodules, typically associated with tuberous sclerosis.
Full Definition
Subependymal giant cell astrocytoma (SEGA) is a rare WHO grade I tumor that develops from pre-existing subependymal nodules in patients with tuberous sclerosis complex (TSC). These tumors are characterized by large, bizarre multinucleated giant cells with abundant eosinophilic cytoplasm and prominent nucleoli. SEGAs typically arise near the foramen of Monro and can cause obstructive hydrocephalus. Despite their low histological grade, they can be clinically significant due to their location and potential for growth. The tumor cells show mixed glial and neuronal features and are positive for both GFAP and neuronal markers.
Usage
Usage note: Always consider tuberous sclerosis complex association.
In Context
- "The tuberous sclerosis patient developed a subependymal giant cell astrocytoma causing hydrocephalus." — Pediatric neurosurgery report
- "Histology confirmed subependymal giant cell astrocytoma with characteristic multinucleated giant cells." — Surgical pathology report