tau protein
Pronunciation: taw PRO-teen
A microtubule-associated protein that forms pathological tangles in Alzheimer's disease and related neurodegenerative disorders.
Full Definition
Tau protein is a normal component of neurons that stabilizes microtubules, but becomes hyperphosphorylated and forms neurofibrillary tangles in various neurodegenerative diseases collectively known as tauopathies. These include Alzheimer's disease, frontotemporal dementia, and progressive supranuclear palsy. In neuropathological contexts, tau protein is frequently referenced in immunohistochemical studies and biomarker discussions. Editors must distinguish between normal tau function and pathological tau aggregation when reviewing research manuscripts and diagnostic reports.
Usage
Usage note: Distinguish from other neurodegenerative protein markers; specify phosphorylation status when relevant.
In Context
- "Tau protein immunostaining revealed extensive neurofibrillary tangles in the hippocampal formation." — Autopsy neuropathology report
- "CSF tau levels were significantly elevated compared to age-matched controls." — Biomarker study manuscript