cholinesterase inhibitor
Medication that blocks acetylcholinesterase to increase acetylcholine levels in synapses.
Full Definition
Cholinesterase inhibitors represent the primary pharmacological treatment for Alzheimer's disease by preventing breakdown of acetylcholine, thereby enhancing cholinergic neurotransmission in areas affected by the disease. Common agents include donepezil, rivastigmine, and galantamine, each with distinct pharmacokinetic properties and side effect profiles. These medications provide modest symptomatic benefit for cognitive and functional decline but do not alter disease progression. Clinical documentation should specify the particular agent, dosing considerations, and monitoring for gastrointestinal and cardiac side effects.
Usage
Usage note: Distinguish from anticholinergics, which have opposite effects on cholinergic transmission.
In Context
- "The patient was started on donepezil, a cholinesterase inhibitor, for mild cognitive impairment." — Memory clinic consultation
- "Cholinesterase inhibitor therapy showed modest improvement in ADAS-cog scores." — Clinical trial report