hyperfractionated radiotherapy
A radiation therapy technique delivering multiple smaller doses per day to increase the total dose while potentially reducing late toxicity.
Full Definition
Hyperfractionated radiotherapy is a specialized radiation treatment approach that divides the total radiation dose into multiple smaller fractions delivered more than once daily, typically twice per day. This technique aims to exploit the differential repair capabilities between tumor cells and normal tissues, potentially allowing for dose escalation while maintaining acceptable toxicity levels. In neurosurgical oncology, hyperfractionated radiotherapy may be used for certain brain tumors, particularly in pediatric cases or when attempting to overcome radioresistance. The increased number of fractions requires careful treatment planning and patient compliance with the intensive schedule.
Usage
Usage note: Specify dose per fraction and interfraction interval when documenting this treatment approach.
In Context
- "The pediatric brainstem glioma patient received hyperfractionated radiotherapy at 1.2 Gy twice daily." — Treatment protocol
- "Hyperfractionated radiotherapy showed promise in improving local control for anaplastic astrocytoma." — Clinical trial report