molecular profiling
Comprehensive genetic and molecular analysis of tumor tissue to guide treatment decisions and prognosis.
Full Definition
Molecular profiling in neurosurgical oncology involves analyzing tumor tissue for specific genetic mutations, protein expressions, and molecular markers that influence treatment selection and prognosis. Key markers include IDH mutations, 1p/19q codeletion, MGMT promoter methylation, and EGFR amplification. This analysis has become standard practice following the 2016 WHO classification update, which integrated molecular parameters with histological features for brain tumor diagnosis. Results directly impact treatment protocols, with some therapies specifically indicated for certain molecular subtypes. Editorial staff should understand this represents a paradigm shift toward precision medicine in neuro-oncology.
Usage
Usage note: Hyphenate as shown. Results should reference specific markers with proper capitalization (e.g., IDH, MGMT).
In Context
- "Molecular profiling revealed IDH-wildtype status confirming the glioblastoma diagnosis." — Pathology report
- "Treatment recommendations were modified based on the molecular profiling results showing MGMT methylation." — Tumor board discussion