molecular subtyping
Classification of brain tumors based on genetic and molecular characteristics rather than solely on histological appearance.
Full Definition
Molecular subtyping represents a paradigm shift in brain tumor classification, using genetic and molecular markers to define tumor subtypes beyond traditional histological criteria. Key molecular markers in neurosurgical oncology include IDH mutations, 1p/19q codeletion, MGMT methylation status, and BRAF alterations. The 2016 WHO Classification of CNS Tumors incorporated molecular parameters for the first time, fundamentally changing diagnostic algorithms. Molecular subtyping provides more accurate prognosis prediction and guides targeted therapies, making it essential for personalized treatment approaches in modern neuro-oncology practice.
Usage
Usage note: Increasingly important in modern practice; often determines treatment protocols more than histological grade.
In Context
- "Molecular subtyping revealed an IDH-wildtype glioblastoma with unmethylated MGMT promoter." — Pathology report
- "Treatment decisions were based on molecular subtyping results rather than histology alone." — Multidisciplinary meeting notes