neuraxis dissemination
The spread of tumor cells through cerebrospinal fluid pathways to distant sites within the central nervous system.
Full Definition
Neuraxis dissemination refers to the spread of malignant cells through cerebrospinal fluid pathways from a primary brain or spinal cord tumor to distant locations within the central nervous system. This process, also known as CSF seeding or drop metastases, commonly occurs with high-grade tumors such as medulloepithelioma, ependymoma, and certain types of glioblastoma. Tumor cells can implant anywhere along the neuraxis, including the ventricles, cisterns, or spinal subarachnoid space. Diagnosis typically requires CSF cytological examination and neuraxis imaging, and treatment often involves craniospinal radiation therapy to address potential microscopic disease throughout the CNS.
Usage
Usage note: Requires comprehensive neuraxis imaging for accurate staging assessment.
In Context
- "Neuraxis dissemination was detected on the staging MRI with multiple enhancing nodules along the spinal canal." — Imaging report
- "The high risk of neuraxis dissemination necessitated craniospinal radiotherapy in this medulloepithelioma case." — Treatment planning note