neuropil thread
Pronunciation: NYUR-oh-pil thread
Fine fibrillary processes observed in certain brain tumors, particularly helpful in diagnosing oligodendrogliomas.
Full Definition
Neuropil threads refer to delicate fibrillary cytoplasmic processes that extend from tumor cell bodies into the surrounding tissue matrix. These structures are characteristically prominent in oligodendrogliomas and represent a key histopathological feature that aids in tumor classification. The threads are best visualized with immunohistochemical staining and appear as fine, hair-like projections that create a distinctive microanatomical pattern. Recognition of neuropil threads is important for pathologists in differentiating oligodendrogliomas from other glioma subtypes, particularly in the context of integrated molecular diagnostics.
Usage
Usage note: Primarily used in pathological contexts and tumor classification discussions.
In Context
- "Histopathological examination revealed abundant neuropil threads consistent with oligodendroglioma." — Pathology report
- "The presence of neuropil threads supported the diagnosis of oligodendroglioma over astrocytoma." — Neuropathology consultation