pseudoprogression
Pronunciation: SOO-doh-proh-GRESH-un
A treatment-related inflammatory response that mimics tumor growth on imaging but represents tissue reaction rather than true progression.
Full Definition
Pseudoprogression is a phenomenon seen in brain tumor patients, particularly those with glioblastoma, where imaging studies show apparent tumor growth that actually represents treatment-related inflammation and tissue necrosis rather than true tumor progression. This typically occurs within the first few months after completion of concurrent chemoradiation therapy. The imaging changes can be identical to actual tumor progression, making clinical distinction challenging. Advanced imaging techniques and sometimes tissue sampling may be needed to differentiate pseudoprogression from true progression.
Usage
Usage note: Critical to distinguish from true progression in treatment response assessments.
In Context
- "Advanced MRI techniques were used to distinguish pseudoprogression from true tumor growth." — Radiology interpretation
- "The patient's imaging changes were consistent with pseudoprogression rather than treatment failure." — Oncology consultation