temozolomide
Pronunciation: tem-oh-ZOH-loh-myde
Also written as: TMZ — temozolomide
An alkylating chemotherapy agent commonly used in treating glioblastoma and other brain tumors.
Full Definition
Temozolomide is an oral alkylating chemotherapy drug that is the standard of care for treating glioblastoma multiforme and other high-grade gliomas. It works by methylating DNA, leading to cancer cell death. The drug can cross the blood-brain barrier, making it particularly valuable in brain tumor treatment. It is typically administered in combination with radiation therapy (concurrent phase) followed by adjuvant cycles. The drug is often abbreviated as TMZ in clinical documentation.
Usage
Usage note: Brand name Temodar may be used but generic name preferred in formal documentation.
In Context
- "The patient tolerated the temozolomide regimen with minimal side effects." — Oncology progress note
- "Concurrent temozolomide and radiation therapy followed the Stupp protocol." — Treatment protocol document