tumor recurrence
Return or regrowth of neoplastic tissue following initial treatment, either at the original site or distant location.
Full Definition
Tumor recurrence represents the return or regrowth of neoplastic tissue following initial treatment in neurosurgical oncology. Recurrence can manifest as local regrowth at the original tumor site, distant spread within the central nervous system, or rarely as systemic metastases. The timing, location, and pattern of recurrence vary significantly based on tumor type, grade, initial treatment, and molecular characteristics. Early detection of recurrence is crucial for timely intervention and optimal outcomes. Surveillance protocols typically involve serial imaging studies, clinical examinations, and sometimes advanced techniques like perfusion imaging or PET scanning to distinguish recurrence from treatment-related changes such as radiation necrosis. Management of recurrent disease often requires multimodal approaches including repeat surgery, salvage radiation, or systemic therapy.
Usage
Usage note: Distinguish from progression (growth of residual disease) and pseudoprogression.
In Context
- "MRI findings suggested tumor recurrence rather than treatment-related changes." — follow-up imaging report
- "The patient developed tumor recurrence 18 months following initial gross total resection." — clinical progression note