cutoff value
The predetermined threshold used to distinguish normal from abnormal screening results.
Full Definition
A statistically determined value that separates normal from potentially abnormal results in newborn screening tests. Cutoff values are carefully calibrated to minimize both false positives and false negatives while maintaining program sensitivity. These values may vary by laboratory, testing method, and population demographics, and are regularly reviewed and adjusted based on program performance data.
Usage
Usage note: Hyphenate when used as an adjective (cutoff-value determination).
In Context
- "The laboratory raised the cutoff value after reviewing false positive rates." — Quality improvement report
- "Results above the cutoff value require immediate follow-up testing." — Laboratory protocol