amniocentesis
Pronunciation: am-nee-oh-sen-TEE-sis
A diagnostic test involving needle extraction of amniotic fluid for genetic and developmental analysis.
Full Definition
A prenatal diagnostic procedure typically performed between 15-20 weeks of pregnancy, involving the insertion of a thin needle through the maternal abdomen into the amniotic sac to extract a small amount of amniotic fluid. The fluid contains fetal cells that can be analyzed for chromosomal abnormalities (such as Down syndrome), genetic disorders, and neural tube defects. The procedure is usually offered to women at increased risk due to maternal age, family history, or abnormal screening results. While generally safe, there is a small risk of miscarriage and other complications.
Usage
Usage note: Often abbreviated as 'amnio' in informal clinical discussion.
In Context
- "Amniocentesis revealed a normal 46,XX karyotype with no detectable abnormalities." — Genetic counseling report
- "The patient declined amniocentesis after extensive counseling about risks and benefits." — Maternal-fetal medicine consultation