choriocarcinoma
Pronunciation: kawr-ee-oh-kahr-suh-NOH-muh
Malignant gestational trophoblastic tumor that can follow any type of pregnancy.
Full Definition
Choriocarcinoma is a rare but highly malignant form of gestational trophoblastic disease characterized by abnormal proliferation of trophoblastic tissue. It can occur following any type of pregnancy, including normal pregnancies, miscarriages, ectopic pregnancies, or molar pregnancies. The tumor produces high levels of beta-hCG and has a high propensity for metastasis, commonly spreading to the lungs, brain, liver, and vagina. Despite its aggressive nature, choriocarcinoma is highly responsive to chemotherapy when diagnosed early, with cure rates exceeding 95% in most cases.
Usage
Usage note: Part of gestational trophoblastic disease spectrum; requires immediate oncology referral.
In Context
- "Rising beta-hCG levels six months postpartum raised suspicion for choriocarcinoma." — oncology consultation report
- "Metastatic choriocarcinoma was diagnosed following chest imaging for persistent cough." — pathology report