chemoreduction
Pronunciation: KEE-mo-ree-DUK-shun
Systemic chemotherapy used to reduce tumor size in retinoblastoma, often enabling globe-preserving treatments.
Full Definition
Chemoreduction is a treatment strategy in retinoblastoma management that uses systemic chemotherapy to reduce tumor volume and viability, thereby facilitating subsequent local therapies such as laser photocoagulation, cryotherapy, or brachytherapy. Common chemotherapeutic agents include carboplatin, etoposide, and vincristine, typically administered in multiple cycles. This approach has revolutionized retinoblastoma treatment by significantly increasing the rate of globe preservation, particularly in eyes that would previously have required enucleation. Chemoreduction is often combined with local consolidative treatments to achieve optimal tumor control while minimizing systemic toxicity and preserving visual function.
Usage
Usage note: Distinguish from 'chemoconsolidation' which refers to chemotherapy given after local treatment completion.
In Context
- "Six cycles of chemoreduction achieved significant tumor regression enabling focal laser therapy." — Pediatric oncology treatment summary
- "Chemoreduction protocols have improved globe salvage rates from 40% to over 90%." — Clinical outcomes research paper