choroidal melanoma
Pronunciation: KOR-oy-dal mel-ah-NO-mah
The most common primary intraocular malignancy in adults, arising from melanocytes in the choroidal layer of the eye.
Full Definition
Choroidal melanoma is the most frequent primary intraocular malignancy in adults, originating from pigmented melanocytes within the choroidal vascular layer. This tumor typically presents as a dome-shaped or mushroom-shaped mass and can metastasize to the liver in up to 50% of cases. Early detection and treatment are crucial for preserving vision and preventing systemic spread. Risk factors include light eye color, fair skin, and certain genetic mutations.
Usage
Usage note: Always specify 'choroidal' to distinguish from cutaneous melanoma when used in oncology contexts.
In Context
- "The patient was diagnosed with a large choroidal melanoma measuring 12mm in basal diameter." — Ophthalmology consultation report
- "Genetic testing revealed BAP1 mutations in 47% of choroidal melanoma cases." — Research publication