cytogenetic analysis
Laboratory examination of tumor chromosomes to identify genetic abnormalities that predict prognosis and guide treatment.
Full Definition
Cytogenetic analysis in ocular oncology involves the detailed examination of tumor cell chromosomes to identify specific genetic abnormalities that have prognostic and therapeutic implications. Common abnormalities analyzed include monosomy 3, chromosome 8q gain, and chromosome 6p gain in uveal melanoma. This analysis can be performed using various techniques including karyotyping, fluorescence in situ hybridization (FISH), and comparative genomic hybridization. Results help stratify patients into risk categories for metastasis and may influence surveillance protocols and treatment decisions.
Usage
Usage note: Distinguish from gene expression profiling, which examines RNA rather than chromosomes.
In Context
- "Cytogenetic analysis revealed monosomy 3 and 8q gain, indicating high metastatic risk." — Laboratory report
- "The tumor sample was sent for cytogenetic analysis to determine prognosis." — Treatment planning note