Flexner-Wintersteiner rosettes
Pronunciation: FLEX-ner VIN-ter-sty-ner ro-ZETS
Pathognomonic histological structures in retinoblastoma characterized by radially arranged cells around a central lumen. Diagnostic hallmark of retinal origin.
Full Definition
Distinctive histopathological structures found exclusively in retinoblastoma, consisting of tumor cells arranged radially around a central lumen, resembling primitive neural rosettes. These structures are pathognomonic for retinoblastoma and help distinguish it from other intraocular tumors. Named after pathologists Simon Flexner and Hugo Wintersteiner, their presence confirms retinal origin of the tumor and is crucial for definitive histopathological diagnosis.
Usage
Usage note: Always hyphenate 'Flexner-Wintersteiner' and capitalize both surnames as eponymous terms.
In Context
- "Histopathology confirmed retinoblastoma with numerous Flexner-Wintersteiner rosettes." — pathology report
- "The presence of Flexner-Wintersteiner rosettes established the diagnosis definitively." — diagnostic summary