peripapillary atrophy
Pronunciation: pair-ih-pap-ih-LAIR-ee AT-roh-fee
Loss of retinal pigment epithelium and choriocapillaris around the optic disc, often associated with intraocular tumors.
Full Definition
Peripapillary atrophy refers to the gradual loss of retinal pigment epithelium (RPE) and underlying choriocapillaris in the region surrounding the optic nerve head. In ocular oncology, this finding can indicate tumor-related vascular compromise or direct tumor extension. The atrophy may be categorized as alpha-zone (irregular RPE depigmentation) or beta-zone (complete absence of RPE with visible choroidal vessels). Recognition of peripapillary atrophy patterns helps distinguish between benign and malignant processes, particularly when evaluating posterior uveal lesions.
Usage
Usage note: Distinguish from normal physiologic peripapillary changes; document zone classification when relevant.
In Context
- "The ophthalmologist noted progressive peripapillary atrophy adjacent to the choroidal mass, suggesting possible tumor infiltration." — Clinical examination report
- "Beta-zone peripapillary atrophy was documented in serial fundus photographs to monitor tumor proximity to the optic nerve." — Follow-up documentation