circumferential resection margin
Also written as: CRM — Circumferential Resection Margin
The closest distance between tumor and the surgical resection plane around the entire circumference of a specimen, critical for predicting local recurrence.
Full Definition
The circumferential resection margin (CRM) represents the shortest distance between the primary tumor or nodal disease and the circumferential (lateral) margin of surgical resection. This measurement is particularly important in rectal cancer surgery, where the CRM status is a strong predictor of local recurrence and overall survival. A positive CRM (≤1mm from tumor to margin) indicates an increased risk of local recurrence and often necessitates adjuvant therapy. Achieving a negative CRM requires meticulous surgical technique and understanding of anatomical planes. The assessment of CRM is performed by pathologists using careful measurement and histological examination of the entire specimen circumference.
Usage
Usage note: Often abbreviated as CRM in clinical documentation; critical measurement in colorectal pathology.
In Context
- "The pathology report confirmed a negative circumferential resection margin of 3mm." — Pathology report
- "Positive circumferential resection margin prompted discussion of adjuvant chemoradiation." — Tumor board presentation