tumor seeding
Inadvertent dissemination of cancer cells during surgical manipulation, potentially causing local or distant recurrence.
Full Definition
Tumor seeding refers to the unintentional spread of viable cancer cells during surgical procedures, which can lead to implantation and growth at new sites. This phenomenon can occur through various mechanisms including direct spillage during tumor manipulation, contamination of surgical instruments, inadequate specimen handling, or breach of tumor capsule. Common sites for seeding include port sites in laparoscopic surgery, needle tracks following biopsy procedures, and the peritoneal cavity during intra-abdominal procedures. Prevention strategies include careful tissue handling, copious irrigation, use of specimen retrieval bags, and avoidance of tumor fragmentation. Understanding seeding risks influences surgical approach selection and technique refinement.
Usage
Usage note: Distinguish from natural tumor spread; specify the mechanism (spillage, instrument contamination, etc.) when describing seeding events.
In Context
- "Careful tissue handling and specimen containment are essential to prevent tumor seeding during minimally invasive surgery." — Surgical technique guide
- "The risk of tumor seeding must be weighed against the benefits of diagnostic tissue sampling." — Clinical decision-making note