odontogenic keratocyst
A benign but aggressive cystic lesion arising from dental tissues, characterized by high recurrence rates and association with nevoid basal cell carcinoma syndrome.
Full Definition
An odontogenic keratocyst (OKC) is a developmental cyst that originates from remnants of the dental lamina or odontogenic epithelium. These lesions are distinguished by their aggressive behavior, tendency to recur if incompletely excised, and characteristic histological features including a corrugated keratin surface. OKCs are most commonly found in the posterior mandible and can cause significant bone destruction. They may occur sporadically or as part of nevoid basal cell carcinoma syndrome (Gorlin syndrome). Treatment typically requires complete enucleation with careful inspection of the cyst lining to prevent recurrence.
Usage
Usage note: Preferred over the older term 'keratocyst' when referring specifically to odontogenic origin.
In Context
- "The radiographic appearance of the odontogenic keratocyst showed a well-defined multilocular radiolucency in the left mandibular body." — Surgical case report
- "Complete enucleation of the odontogenic keratocyst was performed with application of Carnoy's solution to reduce recurrence risk." — Operative note