BRONJ
Pronunciation: BRONJ
Also written as: BRONJ — bisphosphonate-related osteonecrosis of the jaw
Acronym for bisphosphonate-related osteonecrosis of the jaw, a serious complication associated with bisphosphonate therapy.
Full Definition
BRONJ (bisphosphonate-related osteonecrosis of the jaw) is a well-recognized adverse effect of bisphosphonate therapy characterized by exposed, necrotic bone in the oral cavity that persists for more than eight weeks in patients with no history of radiation therapy to the jaw. This condition predominantly affects the mandible and maxilla and is associated with dental extractions, dental implant placement, or other invasive oral procedures. The pathophysiology involves impaired bone remodeling and healing due to bisphosphonate-induced suppression of osteoclast activity.
Usage
Usage note: Now often referred to as MRONJ (medication-related osteonecrosis of the jaw) to include other medications beyond bisphosphonates.
In Context
- "The patient's history of alendronate therapy raised concerns about potential BRONJ development following the planned extraction." — Pre-surgical risk assessment
- "Conservative management of BRONJ included antimicrobial mouth rinses and oral antibiotics." — Treatment protocol documentation