Advanced
Technical
IVT
bone marrow infiltration
Invasion of malignant cells into the bone marrow space, indicating advanced local disease or hematogenous spread.
Full Definition
Bone marrow infiltration occurs when tumor cells invade the medullary cavity of bones, either as direct extension from a primary bone tumor or as metastatic disease. This finding has significant prognostic implications and influences staging, treatment planning, and surgical approach. In primary bone sarcomas, extensive marrow involvement may contraindicate limb salvage surgery. Detection requires advanced imaging, particularly MRI, and may be confirmed through bone marrow biopsy in cases of suspected hematologic malignancy.
Usage
Usage note: Distinguish from normal marrow signal changes or post-treatment effects.
In Context
- "MRI revealed extensive bone marrow infiltration throughout the femoral shaft." — Radiology report
- "The degree of bone marrow infiltration influenced the decision against limb-sparing surgery." — Surgical planning note
Also known as
marrow invasion
medullary infiltration
Contrasted with
cortical containment
extraosseous extension
Don't confuse with
bone marrow edema
marrow replacement