propofol infusion syndrome
Rare but potentially fatal complication associated with prolonged high-dose propofol infusions.
Full Definition
Propofol infusion syndrome is a rare but serious condition characterized by metabolic acidosis, rhabdomyolysis, cardiac arrhythmias, heart failure, and potential death, associated with prolonged administration of high-dose propofol. While more commonly described in critically ill patients, cases have been reported in pediatric patients, particularly those receiving propofol for prolonged sedation. Risk factors include young age, critical illness, high propofol doses, prolonged infusion duration, and concurrent catecholamine or steroid administration. Recognition requires high clinical suspicion and immediate discontinuation of propofol with supportive care.
Usage
Usage note: Often abbreviated as PIS in critical care settings; distinguish from PRIS
In Context
- "Concern for propofol infusion syndrome prompted discontinuation of the sedation infusion after 48 hours." — ICU consultation note
- "The development of unexplained acidosis raised suspicion for propofol infusion syndrome." — Critical care documentation