epidermolysis bullosa
Pronunciation: ep-uh-dur-MOL-uh-sis buh-LOH-suh
A group of inherited disorders causing skin fragility and blistering from minor trauma in newborns and children.
Full Definition
Epidermolysis bullosa encompasses a spectrum of inherited mechanobullous disorders characterized by skin and mucosal fragility. The condition ranges from localized blistering to severe generalized forms with extracutaneous manifestations. Classification includes simplex, junctional, and dystrophic types based on the level of skin separation. Medical editors must understand the prognostic implications of different subtypes when reviewing pediatric dermatology literature, as terminology precision affects clinical communication and family counseling.
Usage
Usage note: Note the correct spelling with 'y' in epidermolysis, not 'i'. Often abbreviated as EB in clinical contexts.
In Context
- "The neonate's widespread blistering was consistent with junctional epidermolysis bullosa." — clinical assessment
- "Epidermolysis bullosa simplex typically has a better prognosis than dystrophic forms." — patient education material