aromatase inhibitor
Pronunciation: ah-ROM-ah-tase in-HIB-ih-tor
Medication that blocks estrogen synthesis, sometimes used to delay bone maturation and preserve growth potential.
Full Definition
A class of medications that inhibit the aromatase enzyme, which converts androgens to estrogens. In pediatric endocrinology, aromatase inhibitors such as anastrozole or letrozole are sometimes used off-label in boys with short stature to delay bone age advancement and potentially improve final adult height. The rationale is that estrogen is the primary hormone responsible for epiphyseal fusion in both sexes. These medications may also be used in boys with aromatase excess syndrome or peripheral precocious puberty. Long-term safety data in children is limited, making careful monitoring essential.
Usage
Usage note: Always specify off-label use and obtain appropriate informed consent in pediatric patients.
In Context
- "The aromatase inhibitor was prescribed to slow bone age advancement in the short-statured adolescent male." — Treatment plan
- "Aromatase inhibitor therapy requires careful monitoring of bone density and lipid profiles." — Safety protocol